All Blogs | Help | Support | About
x This LabTrove instance has just been upgraded to 2.3, to see what new check out the documentation, http://www.labtrove.org/documentation/
10th December 2012 @ 03:26
Biological evaluation of OSM-S-96 through 105 performed by Vicky Avery's lab by Sabine Fletcher.

Structures:
Compound Structures


PDF summarising data:
PDF Summary of Curves


Excel sheet of raw data:
Raw Biological Data


Comments from Sabine:
Unfortunately, none of the cpds was active enough on 3D7 to obtain an
IC50 curve (only cpd OSM-S-103 showed 61% inhibition at the highest dose).

Slight solubility issues etc. after thorough vortexing were as follows:

OSM-S-100: very few, tiny undissolved crystals
OSM-S-101: few floating specks that looked like dust / cotton wool
OSM-S-104: few floating specks of different colour: white (cotton
wool?) large black 'chip' (plastic from lid?) and tiny orange specks (undissolved crystals?)
OSM-S-105: had cotton wool in lid. I 'flushed' the cotton wool
thoroughly with DMSO to dissolve all compound on the cotton wool and
then discarded the wool.

Places where these results are discussed:
G+


InChIs:
(need to insert)
Linked Posts
Attached Files
Compound Structures
PDF Summary of Curves
Raw Biological Data
Comments
Re: Biological Activities of OSM-S-96 through 105 by Alice Williamson
10th December 2012 @ 08:01
OSM-S-96
InChI=1S/C15H12FN3O3/c1-9-12(14-18-13(8-22-14)15(20)21-2)7-17-19(9)11-5-3-10(16)4-6-11/h3-8H,1-2H3
OSM-S-97
InChI=1S/C16H16FNO3/c1-10-9-14(15(19)7-8-16(20)21)11(2)18(10)13-5-3-12(17)4-6-13/h3-6,9H,7-8H2,1-2H3,(H,20,21)
OSM-S-98
InChI=1S/C18H21FN2O2/c1-12-11-16(17(22)9-10-18(23)20(3)4)13(2)21(12)15-7-5-14(19)6-8-15/h5-8,11H,9-10H2,1-4H3
OSM-S-99
InChI=1S/C18H20FNO4/c1-5-23-17(21)13(4)24-18(22)16-10-11(2)20(12(16)3)15-8-6-14(19)7-9-15/h6-10,13H,5H2,1-4H3
OSM-S-100
InChI=1S/C16H16FNO4/c1-9-8-14(16(21)22-11(3)15(19)20)10(2)18(9)13-6-4-12(17)5-7-13/h4-8,11H,1-3H3,(H,19,20)
OSM-S-101
InChI=1S/C16H13FN2O3/c1-9-7-13(15-18-14(8-22-15)16(20)21)10(2)19(9)12-5-3-11(17)4-6-12/h3-8H,1-2H3,(H,20,21)
OSM-S-102
InChI=1S/C17H19FN2O2/c1-11-10-15(16(21)8-9-17(22)19-3)12(2)20(11)14-6-4-13(18)5-7-14/h4-7,10H,8-9H2,1-3H3,(H,19,22)
OSM-S-103
InChI=1S/C16H17FN2O2/c1-10-9-14(15(20)7-8-16(18)21)11(2)19(10)13-5-3-12(17)4-6-13/h3-6,9H,7-8H2,1-2H3,(H2,18,21)
OSM-S-104
InChI=1S/C14H10FN3O3/c1-8-11(13-17-12(7-21-13)14(19)20)6-16-18(8)10-4-2-9(15)3-5-10/h2-7H,1H3,(H,19,20)
OSM-S-105
InChI=1S/C14H11FN4O2/c1-8-11(14-18-12(7-21-14)13(16)20)6-17-19(8)10-4-2-9(15)3-5-10/h2-7H,1H3,(H2,16,20)