x
This LabTrove instance has just been upgraded to 2.3, to see what new check out the documentation, http://www.labtrove.org/documentation/
This Post
PermalinkURI
URI Label
Revisions
Export:
XML
Archives
- May 2013 (1)
- April 2013 (1)
- February 2013 (2)
- January 2013 (1)
- December 2012 (2)
- November 2012 (1)
- October 2012 (2)
- July 2012 (2)
- May 2012 (4)
- April 2012 (2)
- March 2012 (2)
- January 2012 (3)
Authors
Sections
- 3D7 IC50 Avery Lab (3)
- Biology (19)
- GSH-EE - Chapman Lab (1)
Tools
Show/Hide QR CodeShow/Hide Keys
Data acquired by Karen White External Projects Coordinator, Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia
Assessed the stability of OSM-S-5 in human and mouse plasma. The compound was stable in human plasma but susceptible to hydrolysis in mouse plasma. Esterase activity is known to be higher in rodents than in other species which was confirmed using a control compound in this assay (p-nitrophenol acetate) so the results are not too surprising.
Mouse plasma: Half-life: 114 minutes, 25% remaining after 240 minutes
Human plasma: No measurable loss after 240 minutes.
Data:
Assessed the stability of OSM-S-5 in human and mouse plasma. The compound was stable in human plasma but susceptible to hydrolysis in mouse plasma. Esterase activity is known to be higher in rodents than in other species which was confirmed using a control compound in this assay (p-nitrophenol acetate) so the results are not too surprising.
Mouse plasma: Half-life: 114 minutes, 25% remaining after 240 minutes
Human plasma: No measurable loss after 240 minutes.
Data:
Plasma Stability
Linked Posts
Attached Files
Plasma Stability