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10th July 2012 @ 06:53
Data acquired by Karen White External Projects Coordinator, Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia

Assessed the stability of OSM-S-5 in human and mouse plasma. The compound was stable in human plasma but susceptible to hydrolysis in mouse plasma. Esterase activity is known to be higher in rodents than in other species which was confirmed using a control compound in this assay (p-nitrophenol acetate) so the results are not too surprising.

Mouse plasma: Half-life: 114 minutes, 25% remaining after 240 minutes
Human plasma: No measurable loss after 240 minutes.

Data:
Plasma Stability
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Plasma Stability