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10th December 2014 @ 14:10

Biological activities of OSM-S-106 and PT-22-C1 performed at the Dundee Drug Discovery Unit by Irene Hallyburton.

OSM-S-106 was resynthesised in Edinburgh (PT-23-C1) and found to have an activity of 150 nM, consistent with that reported as TCMDC 135294 but a little lower than the Avery results. Adding a methyl group to improve solubility by introducing an axial twist gave PT-22-C1, which was inactive.

 

 

 

 

OSM-S-106 and PT-22-C1.pdf
Attached Files
OSM-S-106 and PT-22-C1.png
OSM-S-106 and PT-22-C1.pdf