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11th November 2013 @ 03:48

Repeat of AEW 100-4 with monitoring after 2 h

Procedure:

AT-5 (100 mg, 0.4 mmol, 1.0 equiv.), isopropanol (2 mL) and ammonia (4 mL) were stired in a sealed tube and then heated to 120 ˚C [blast shield in place] for 2 hours 


Data:

 

Hazard and Risk Assessment:

See: Amination of bromochlorothienopyrimidine (AT-6-4) 

InChi:

InChI=1S/C6H2BrClN2S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H

to 

InChI=1S/C6H4BrN3S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H,(H2,8,9,10)