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22nd October 2013 @ 04:23

Methylamine (24% w/v in H2O, 5 mL) was added to MNR 99-3 (175 mg, 0.7 mmol),. The mixture was stirred at 85 ˚C overnight.

Reaction mixture was cooled to room temperature and then water (20 mL) was added and the product was extracted with EtOAc (3 x 20 mL). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated to give a yellow solid. 1H NMR showed desired product along with some impurities.

Data:

AEW 98-1 crude proton.pdf
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Hazard and Risk Assessment:

See Bromination of chlorothienopyrimidine (AT-5-5)

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AEW 98-1.cdx
AEW 98-1.png
AEW 98-1 crude proton.pdf
fid