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8th July 2013 @ 08:32

Repeat of See Synthesis of 4-(4-Methylpiperazin-1-yl)thieno[3,2-d]pyrimidine (AEW 55-1)

Procedure:

To MNR 99-3 (500 mg, 2.93 mmol, 1 equiv) in THF (3.5 mL) (ethanol (2.5 mL added to get the starting material into solution) was added 1-methylpiperazine (0.49 mL, 4.40 mmol, 1.5 equiv) at 0 ˚C and the reaction mixture was stirred overnight at room temperature. Volatiles were removed in vacuo and then the white suspension was dissolved in EtOAc, washed with a saturated aqueous solution of sodium hydrogen carbonate, brine, dried (MgSO4) and evaporated to give a yellow oil which solidified at the high vac to give a yellow solid 

Data:

AEW 55-2, EtOAc.jpg

Hazard and Risk Assessment:

See Synthesis of 4-(4-Methylpiperazin-1-yl)thieno[3,2-d]pyrimidine (AEW 55-1)

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AEW 55-2, EtOAc.jpg